HYPOPITUITARISM IN LANGERHANS CELL HISTIOCYTOSIS SEVEN CASES AND LITERATURE REVIEW

HYPOPITUITARISM IN LANGERHANS CELL HISTIOCYTOSIS SEVEN CASES AND LITERATURE REVIEW

Sella-suprasellar mass in a patient with Erdheim—Chester disease.. Clin Endocrinol Oxf , 53 , pp. Blood, , pp. Histiocytosis is characterized by proliferation of cells from the mononuclear phagocyte system, and may be divided into Langerhans cell histiocytosis LCH and non-Langerhans cell histiocytosis including Erdheim—Chester disease [ECD]. Because of the lower frequency of ECD, these two cases in our series are described.. Treatment of patients with hypothalamic—pituitary lesions as adult-onset Langerhans cell histiocytosis.

Se continuar a navegar, consideramos que aceita o seu uso. Pages February Endocrine manifestations in Langerhans cell histiocytosis. As regards ECD, the first guidelines for its diagnosis and clinical management have recently been published. At this follow-up visit the patient was clinically well, but the skeletal isotope scan revealed areas of abnormally increased uptake in the anterior aspects of the 7th and 8th ribs on the right side. Material and methods A retrospective, observational study was conducted to analyze the clinical data from nine patients 5 women and 4 men with a mean age 52 years range, 21—74 with a histological diagnosis of histiocytosis and HPA involvement 7 with LCH and 2 with ECD.

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hypopituitarism in langerhans cell histiocytosis seven cases and literature review

Langerhans cell histiocytosis infiltration into pancreas and kidney. Pediatr Blood Cancer, 49pp. Age at end of follow-up.

Langerhans cell Histiocytosis in adults. Treatment of patients with hypothalamic—pituitary lesions as adult-onset Langerhans cell histiocytosis.

A retrospective, langerans study was conducted to analyze the clinical data from nine patients 5 women and 4 men with a mean age 52 years range, 21—74 with a histological diagnosis of histiocytosis and HPA involvement 7 with LCH and 2 with ECD. Its clinical heterogeneity is illustrated by the fact that it was historically described as three different disease entities, based on disease extent and severity.

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Current therapy for Langerhans cell histiocytosis. Two patients with LCH with systemic involvement received chemotherapy, which also achieved disease stabilization.

Hypopituitarism in langerhans cell histiocytosis: seven cases and literature review.

During follow-up, the sellar and parasellar masses increased in size, requiring repeat surgery and the subsequent administration of fractionated stereotactic RT. SRJ is a prestige metric based on the idea that not all citations are the same. Morbidity, treatment, and course.

Central nervous system disease in Langerhans cell histiocytosis. A final diagnosis of LCH with multifocal skeletal involvement only was made.

hypopituitarism in langerhans cell histiocytosis seven cases and literature review

Base of skull TD Treatment was started with glucocorticoids and azathioprine, with no response. Histiocytosis follows an unpredictable course, sometimes consisting of bouts of the disease.

Biol Blood Marrow Transplant ;16 1: The staging investigations excluded any organ dysfunction. Kennedy’s disease and partial androgen insensitivity Langerhans cell histiocytosis in Turkish children. Median follow-up time was 12 years range, 4— Pituitary hypopititarism thickening in a patient with Langerhans cell histiocytosis.

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Hypopituitarism in langerhans cell histiocytosis: seven cases and literature review.

Multivisceral involvement bone, orbital tissue, retroperitoneum, mediastinum, and adrenal was found in one patient. Pituitary TD 10 Gy caes. Regular monitoring of these patients is recommended.

Sellar and suprasellar mass 0 and 1. Cutaneous Langerhans cell histiocytosis in children under one year. Features of LCH that indicate a poor prognosis hypkpituitarism age of less than 2 years at diagnosis, any risk organ involvement bone marrow, blood, liver and spleenorgan dysfunction, multi-system disease and unsatisfactory response to initial treatment.

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Hypothalamo-pituitary abnormalities in adult patients with Langerhans cell histiocytosis: Treatment with oral prednisone was restarted, leading to langerhanw stabilization of the condition, and continues to date. Today most investigators consider LCH to result from an aberrant immune response, but the stimulus for clonal Langerhans cell proliferation remains unknown.

This was a year-old male patient who reported polyuria-polydipsia syndrome in